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Agranulocytosis
DESCRIPTION Agranulocytosis is a condition caused by lack of or insufficient number of granulocyte type white blood cells. This can cause an individual to become susceptible to an infection or can be caused when white blood cells are destroyed faster than they can be produced.
HERBS OF CHOICE Herbs are often used in combinations when combating an illness. Some of the most frequently used herbs are listed below. These nine herbs were picked up from different herbal combinations and are not meant to form a recipe. Our reference code for the different combinations of herbs used for this condition is HGL. This listing is not meant to diagnose, only to inform. This is of course not a complete list and is not meant to be used in the place of a doctor's advice. Click the image of each herb for a brief introduction in terms of Traditional Chinese Medicine.
CLINICAL SUCCESS IN CHINA Chinese herbal doctors have reported some successful applications of these herbal combinations. During observation on 128 patients receiving treatment with herbal remedy, 102 cases were judged as healing (full recovery and symptom free), 16 cases other significant improvement. Physicians judged the clinical efficacy to be good or excellent in 92.2%. Check the table below for details.
Cases
Healing
Improvement
Total
cases
%
128
102
16
118

92. 2

HERBAL REMEDY BEST FOR YOU The most powerful feature of Traditional Chinese Medicine is that it allows you to easily combine multiple ingredients to form a recipe to suit the specific need of individual. The list below are to give you an idea of why you can get the herbal remedy best for you from here with us.

Authoritative Oriented Recipes: All these well chosen herbal combinations source from experienced and authoritative experts, and have been most commonly recognized by the practitioners in this field. When you choose a herbal remedy there are two important things among your concerns: a good recipe and a correct way to cook it. A good recipe is half the good results.

Custom-made with Unique Technology: When you order a herbal remedy at this website you can figure out your symptoms by using our online questionnaire system. In this way a basic herbal recipe could be customized and optimized by adding or removing some herbs to address the individual symptoms exactly. Chinese herbs should not be used in form of standard industrial products manufactured in bulk to cope with all body issues. Only custom-made is the traditional and professional way to use Chinese herbs. All the herbal remedies available at this website are purposed to be custom-made on each single order base. With our unique technology called Low-temperature Concentration the active ingredients of herbs could be survival as much as possible while being concentrated. Eevery 8 ml of the extracts, as one dose, might equal to about 50 grams of raw herbs.
Safe and Side Effect Free: All these herbs have been being used in China for thousands of years, and have been proven to be safe. In fact most Chinese herbs are tonics without side effects. What important is that experienced practitioners should know how to use herbs to avoid possible side effects.
Easy-to-Take Dosage Form: You do NOT need to cook these herbs at all. We get everything ready for you. The herbal remedy comes with the preparation in an easy-to-take dosage form, typically an oral dosage form namely Liquid Herbal Extracts created on a single order base. If necessary other dosage forms, such as pills, capsules, tablets, powder, tea bag, agar gel, rinse, lotion, spray, tincture, liniment, ointment, suppositories, etc., might be used depending on how to use the herbs correctly. And herbal remedy kit, consisting of two different herbal formulae typically one for oral administration and another for external use, is often used for the skin conditions.
Low-cost Customized Service: Three month's supply of this custom-made herbal preparation created on a single order base costs US$399.95 only. It is the average duration to take the remedy for an effect recommended for most individuals with different responses. Shipping charges are not included in the purchase price and will depend upon the shipping method that you choose. Please read our Shipping Policy for details. No any other hidden fees. Click the button below to go to questionnaire and order this herbal remedy.
Clinically, agranulocytosis is defined as having occurred when the concentration of granulocytes in the blood is less than 500 per µL while the concentration of white blood cells in the blood is less than 2000 per µL.
Granulocytes are a type of white blood cell filled with microscopic granules that are little sacs containing enzymes that digest microorganisms.
Granulocytes are part of the innate, somewhat non specific infection-fighting immune system. They do not respond exclusively to specific antigens, as do B-cells and T-cells.
Agranulocytosis results in a syndrome of frequent chronic bacterial infections of the skin, lungs, throat, etc. Although "agranulocytosis" literally means no granulocytes, there may, in fact, be some granulocytes but too few of them, i.e. granulocytopenia. Agranulocytosis can be genetic and inherited or it can be acquired as, for example, an aspect of leukemia.
Neutrophils, eosinophils and basophils are all types of granulocytes. They are named by the staining features of their granules in the laboratory:
  • Neutrophils have "neutral" subtle granules;
  • Eosinophils have prominent granules that stain readily with the acid dye eosin; and
  • Basophils have prominent granules that stain readily basic (non acidic) dyes.
The most frequent cause of Agranulocytosis is exposure to drugs or chemicals:
  • Any chemical or drug that can depress the bone marrow and cause hypoplasia or aplasia is capable of causing agranulocytosis. Some drugs do this to everyone if they are administered in large enough doses. Other agents seem to cause idiosyncratic reactions that affect only certain susceptible individuals.
  • The mechanisms that cause neutropenia are not completely understood. In many cases, neutropenia occurs after prolonged exposure, resulting in decreased neutrophil production by hypoplastic bone marrow. In other cases, repeated but intermittent exposure is needed. This suggests an immune mechanism, although this idea has not been proven.
  • A drug may act as a hapten and induce antibody formation. This mechanism operates in cases due to gold, aminopyrine, and antithyroid drugs. The antibodies destroy the granulocytes and may not require the continued presence of the drug for their action. Alternatively, the drug may form immune complexes that attach to the neutrophils. This mechanism operates with quinidine.
  • Another mechanism is direct inhibition of myelopoiesis. Valproic acid, carbamazepine, and beta-lactam antibiotics fall into this group. In bone marrow cultures, these agents inhibit granulocyte colony formation in a dose-related fashion.
  • Direct damage to the bone marrow microenvironment or myeloid precursors plays a role in most other cases.
Many drugs associated with agranulocytosis have been reported to the US Food and Drug Administration (FDA) under its adverse reactions reporting requirement. Many are also reported to a registry maintained by the American Medical Association. The reported drugs were used alone, in combination with another drug known to be potentially toxic, or with another drug without known toxicity. Several drugs are salient because of their high frequency of association with agranulocytosis. These include the following:
  • Phenothiazine
  • Antithyroid drugs (thiouracil and propylthiouracil)
  • Aminopyrine
  • Phenylbutazone
  • Chloramphenicol
  • Sulfonamides
SYNONYMS
  • Granulocytopenia
  • Granulopenia
  • Neutropenia
  • Malignant neutropenia
  • Primary granulocytopenia
  • Agranulocytic angina
SYMPTOMS
  • Fever
  • Sore throat
  • Painful mouth ulcers
  • Anal ulcers
  • Reduced immune response
  • Prone to bacterial infections
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